2021.11.27 20:48 hexachoron Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD)
The psychopharmacological properties of the psychedelic drug lysergic acid diethylamide (LSD) have attracted the interest of several generations of scientists. Whilst further explorations involving novel LSD-type compounds are needed to assess their potential as medicinal drugs, the emergence of novel derivatives as recreational drugs has also been observed. 1-Valeroyl-LSD (also known as 1-valeryl-LSD, 1-pentanoyl-LSD, 1V-LSD, or "Valerie") is a new N1 -acylated LSD derivative that recently appeared on the online market and it could be viewed as a higher homolog of ALD-52, 1P-LSD, and 1B-LSD. The present study included the analytical characterization and involved various methods of mass spectrometry (MS), gas- and liquid chromatography (GC and LC), nuclear magnetic resonance spectroscopy (NMR), GC solid-state infrared (GC-sIR) analysis and Raman spectroscopy. The in vivo activity of 1V-LSD was assessed using the mouse head twitch response (HTR), a 5-HT2A -mediated head movement that serves as a behavioral proxy in rodents for human hallucinogenic effects. Similar to LSD and other psychedelic drugs, the HTR induced by 1V-LSD was dose-dependent and the median effective dose for 1V-LSD was 373 nmol/kg, which was about a third of the potency of LSD (ED50 = 132.8 nmol/kg). Lysergamides containing the N1 -substituent typically act as weak partial agonists at the 5-HT2A receptor and are believed to serve as prodrugs for LSD. 1V-LSD is also likely to be hydrolyzed to LSD and serve as a prodrug, but studies to assess the biotransformation and receptor pharmacology of 1V-LSD should be performed to fully elucidate its mechanism-of-action.Just came out yesterday so no full text available on sci-hub yet. Anyone have a source for it?
2021.11.27 20:48 UnluckyChemist2162 Is it me or is caustic the most overrated legend there is?
The idea of caustic is incredible. Gas traps that you can deploy all over the place that when shot or an enemy enters the proximity, they trigger, doing area of effect damage to anyone there, but not to you. While you can also actively attack your enemy and do damage to them. That sound absolutely terrific, right? So why does it never work?
It's a great question, honestly. I've never in my apex career been rocked by a cosmic, nor have I ever had one on my team that actually proved to be useful in any way. Not even in the last ring. You would think having someone with area of effect gas traps in a small area would really really help, right? So why do we see so few of this one legend actually performing well and doing a good job compared to the other favorites like Valkyrie, Pathfinder, octane, Gibby, etc?
I personally think it's because his kit provides no survivability advantage whatsoever. It doesn't reduce his damage taken, doesn't help him get out of tight situations really quickly, doesn't reduce the damage allies will take. It literally does not benefit anyone, not the player using it, or the team. All it is is a silly little nuisance to piss a bunch of people off. If the player isn't even good enough to hold his own, or smart enough to know how to position themselves, they will die faster than the enemy will
Yet so many players are so confident in using caustic.. But they never get very far.
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2021.11.27 20:48 Hot_Ruin_391 an illustration of my oc, Emily Fenstar.
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2021.11.27 20:48 According-Durian-309 Acer Nitro 5 w/ Oculus Quest?
Hey there , I just bought an Acer Nitro 5 Intel Core i5 w/ GeForce RTX 3050 to replace my current low budget rig. Will it be able to run VR games Like Blade & Sorcery, Half Life: Alyx & Boneworks?
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2021.11.27 20:48 cuttyhunny I want to relapse.
I want to relapse so badly, I just want to see the gaping wound on my arm. but I can't. because I have to go eat with my family and it's infuriating. fml
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2021.11.27 20:48 WondurPop Made some citycore/carnivalcore paths, what do you guys think?
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2021.11.27 20:48 JohnHalvoe Check out the newest work from John Halvoe at CryptoCom NFT
2021.11.27 20:48 helhady xQc Teaches Pokimane How to Hack a Fleeca
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2021.11.27 20:48 CharlesHurstCanHelp Want to be an artist or actor? Then pursue it smartly
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2021.11.27 20:48 Jackson_Boudreaux Link Group
2021.11.27 20:47 JessAda407 What’s your assumptions? 😄 wondering if it’s different with my hair up 😋
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2021.11.27 20:47 Professional-Cut4602 SOMEONE HELP ME!!!!!!
okay so i play viola and before anyone makes any jokes please read the rest of my post first.
my brother got in trouble for playing video games at one am, and my dad took away his controller. fair enough, right? well, my brother (we share a room) tattled that i was watching twoset. my dad proceeds to TAKE AWAY MY INSTRUMENT and i haven't been able to play since.
this was two weeks ago.
i have extreme anxiety and most days i can't move. playing voila helps that.
please help me i don't know what to do.
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2021.11.27 20:47 RLCD-Bot [Fennec] [Dissolver] [Black Candyfloss] [Cristiano] [Black Lightspeed]
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2021.11.27 20:47 Slickbabydik “How does anything happen? Just move past it!”
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2021.11.27 20:47 throwawayfrdude Redditors who found out you had a child years after what's your story ?
2021.11.27 20:47 gecko_pasta 2 slightly unsettling encounters.
Hi there. So I was just thinking about a time I went on holiday when I was about 14. I don't know if I was overreacting but there were 2 men who just gave off weird vibes.
If this doesn't fit here I'll remove it.
The first guy an old man who had a stall at a flea market. He seemed normal and friendly at first, just haggling and making jokes with my family.
After a while we all turned to talk to someone else so we had our backs to him. As soon as he was out if sight of the adults he came up behind me and whispered in my ear "you wanna come look in my shop?" I ignored him. Nothing happened but just seemed like he was being unnecessarily creepy. Plus I had literally just left his shop.
The next guy tried to sneak up on me when we were in a shop. Again he tried to approach me without any if the adults I was with noticing him. Fortunately my uncle saw, stepped in front of me and just started chatting to the guy.
Again nothing really happened but I just remember both times 14 year old me was creeper out. There were other weird interactions on that holiday including a man aggressively hitting on my mum.to the point she changed the route she walks to feel safe.
Happened on other holidays too. Men only approaching child ne she nobody else is looking.
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2021.11.27 20:47 Floxabia_ My bird approves of his keychain portrait
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2021.11.27 20:47 moe_is_bored Side fact I noticed
Very centrally displayed in Nairobi's and Helsinki's room is Saint Sebastian (the figure Tokyo points out in the flashback scene).
He's the inofficial Patron Saint of gay men/queers in general for following reasons: He was killed by a bunch of arrows and is therefore the patron saint of penetration ;) He's also usually depicted as a handsome young twink, who is almost naked and his facial expression while he is penetrated by the arrows is pained but he also always looks like he's kinda into it lol
anyway, nice set design to have the gay saint in Helsinki's room
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2021.11.27 20:47 Charlie_Ferrari Care after giving diluted peroxide
Can anyone knowledgeable please advise as to whether I should feed my dog this eve or let her digestive system rest?
Context: I had to induce vomiting this pm because she managed to get into a pack of milk chocolate chips while we were out. Called the vet and they advised the peroxide dose. She did vomit.... eventually. I'm uncertain as to whether she brought it all up, but definitely some as it was within an hour. She's been active since, but is now pretty sleepy and her stomach is making the worst loud gurgley sounds.
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2021.11.27 20:47 nathancdavis so i had to change some things because my brother said he wanted to have an red color computer case
2021.11.27 20:47 bot_neen Cuentistas Latinoamericanas 1
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2021.11.27 20:47 Existing_Abalone4949 First Stream
Hello everyone. I'm new to this whole streaming thing. But tonight I'm going to be doing my first stream. I dont have a quality setup or anything. But thats allright because I'm just doing this for fun and to pass the time. I dont want any ones money. That being said, starting at 8pm tonight I'm going to be streaming a Dark Souls 3 challenge run. (I Die, I Drink.
If you find you have some down time, or stumble across this post, feel free to join me for a chat and some laughs as I get progressively more and more drunk Because of Dark Souls.
Have a Wonderful Night everyone!!
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2021.11.27 20:47 caydxn0 Does anyone else have this problem with not enough paint on the moon grays?
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2021.11.27 20:47 Irate_W1zard TURAN 9MM 124GR Full Metal Jacket - New Brass - 200 Round Box - Black Friday Special ( CPR :: 0.32)
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2021.11.27 20:47 Bizy9 When you don't trust someone😁
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